Evasion of I Interferon-Mediated Innate Immunity by Pseudorabies Virus

Evasion of I Interferon-Mediated Innate Immunity by Pseudorabies Virus

Blog Article

Type I interferon (IFN-I) mediated innate immunity serves as the first line of host defense against viral infection, ranging from IFN-I production upon viral detection, IFN-I triggered signaling pathway that induces antiviral gene transcription the antiviral effects of IFN-I induced gene products.During coevolution, Algorithm for scenario benefit route planning based on user’s requests herpesviruses have developed multiple countermeasures to inhibit the various steps involved to evade the IFN response.This mini-review focuses on the strategies used by the alphaherpesvirus Pseudorabies virus (PRV) to antagonize IFN-I mediated innate immunity, with a particular emphasis on the mechanisms inhibiting IFN-I induced gene transcription through Occurrence of anti-Toxoplasma gondii antibody and evaluation of risk infection factors in goats raised in Sergipe state, Brazil the JAK-STAT pathway.

The knowledge obtained from PRV enriches the current understanding of the alphaherpesviral immune evasion mechanisms and provides insight into the vaccine development for PRV control.